• SP600125 and the Future of JNK Pathway Modulation: Strate...

  2025-10-22

  This thought-leadership article examines the mechanistic underpinnings and translational potential of SP600125, a selective ATP-competitive JNK inhibitor. By integrating recent advances in kinase-substrate mapping, competitive landscape analyses, and practical workflow guidance, the article empowers translational researchers to leverage SP600125 for next-generation disease modeling and therapeutic development in inflammation, cancer, and neurodegeneration.

• AT-406 (SM-406) and the Next Frontier in Apoptosis Modula...

  2025-10-21

  This thought-leadership article bridges cutting-edge mechanistic discoveries in death receptor and IAP signaling with actionable strategies for translational researchers. By weaving together atomic-level insights, experimental validation, and the unique pharmacological strengths of AT-406 (SM-406), we illuminate how IAP inhibition is reshaping the landscape of apoptosis-based cancer therapeutics. This piece not only contextualizes AT-406 in the evolving competitive and translational terrain but also charts new directions for research and clinical innovation.

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